zum Inhalt springen

Medizinische Fakultät IPaCT

Wissenschaftliche Artikel

  • Sebeke L, Deenen DA, Maljaars E, De Jager B, Heijman E, Heemels WPMH, Gruell H. A Model Predictive Control Algorithm for Stable Hyperthermia Induced by MR-HIFU. International Journal of Hyperthermia. 2019 (submitted).
  • Ferrer CJ, Bos C, Yoneyama M, Obara M, Kok L, van Leeuwen M, Bleys R, Moonen CT, Bartels LW. Respiratory and cardiac triggered three-dimensional sheath inked rapid acquisition with refocused echoes imaging (SHINKEI) of the abdomen for magnetic resonance neurography of the celiac plexus. Eur radiol exp Epub ahead of print.
  • Kneepkens, E. et al. Interleaved Mapping of Temperature and Longitudinal Relaxation Rate to Monitor Drug Delivery During Magnetic Resonance-Guided High-Intensity Focused Ultrasound-Induced Hyperthermia. Invest Radiol. 52(10), 620-630 (2017).
  • Hijnen, N. et al. Thermal combination therapies for local drug delivery by magnetic resonance-guided high-intensity focused ultrasound. Proceedings of the National Academy of Sciences 114, E4802–E4811 (2017).
  • Ferrer CJ, Bartels LW, van Stralen M, Denis de Senneville B, Moonen CTW, Bos C. Fluid filling of the digestive tract for improved proton resonance frequency shift-based MR thermometry in the pancreas. J Magn Reson Imaging. 2017 Jun 24. doi: 10.1002/jmri.25800.\
  • Ramaekers P, de Greef M, Berriet R, Moonen CTW, Ries M. Evaluation of a novel therapeutic focused ultrasound transducer based on Fermat's spiral. Phys Med Biol. 2017 Jun 21;62(12):5021-5045.
  • Ramaekers P, Ries M, Moonen CT, de Greef M. Improved intercostal HIFU ablation using a phased array transducer based on Fermat's spiral and Voronoi tessellation: A numerical evaluation. Med Phys. 2017 Mar;44(3):1071-1088.
  • Zachiu C, Ries M, Ramaekers P, Guey JL, Moonen CTW, de Senneville BD. Real-time non-rigid target tracking for ultrasound-guided clinical interventions.Phys Med Biol. 2017 Oct 4;62(20):8154-8177.
  • Ramaekers P, de Greef M, van Breugel JM, Moonen CT, Ries M. Increasing the HIFU ablation rate through an MRI-guided sonication strategy using shock waves: feasibility in the in vivo porcine liver. Physics in medicine and biology. 2016;61(3):1057-77. Epub 2016/01/14.
  • Ramaekers P, de Greef M, Moonen CT, Ries MG. Cavitation-enhanced back projection for acoustic rib detection and attenuation mapping. Ultrasound in medicine & biology. 2015;41(6):1726-36. Epub 2015/04/07.
  • Kneidl B, Peller M, Winter G, Lindner LH, Hossann M. Thermosensitive liposomal drug delivery systems: state of the art review. International journal of nanomedicine. 2014;9:4387-98. Epub 2014/09/27.
  • Limmer S, Hahn J, Schmidt R, Wachholz K, Zengerle A, Lechner K, et al. Gemcitabine treatment of rat soft tissue sarcoma with phosphatidyldiglycerol-based thermosensitive liposomes. Pharmaceutical research. 2014;31(9):2276-86. Epub 2014/03/07.

Konferenzbeiträge

  • Sebeke L, Deenen DA, Maljaars E, De Jager B, Heijman E, Heemels WPMH, Gruell H. Model-based control for conformal hyperthermia using MR-HIFU. 6th International Symposium on Focused Ultrasound; Reston, USA, 2018.
  • Ferrer C, Bos C, Denis de Senneville B, Borman P, Tijssen R, Stemkens B, Moonen CT, Bartels LW. A planning strategy for combined self-scanned/gated MR-HIFU treatment in the pancreas. 6th International Symposium on Focused Ultrasound; Reston, USA, 2018.
  • Ferrer C, Bartels LW, Mougenot C, Moonen CT, Bos C. Multichannel fast interleaved non selective free induction decay (FID) readouts for field drift correction of PRFS temperature mapping. Interventional MR symposium, Boston, USA, 2018
  • Esther Kneepkens, Edwin Heijman, Jochen Keupp, Steffen Weiss, Klaas Nicolay† and Holger Grüll. Interleaved scanning for MR-guided High Intensity Focused Ultrasound mediated drug delivery. Joint Annual Meeting ISMRM-ESMRMB; Paris, France, 2018.
  • Edwin Heijman, Nicole Hijnen, Esther Kneepkens, Mariska de Smet, Sander Langereis and Holger Grüll. Synergistic effect of MR-HIFU hyperthermia mediated drug delivery followed by ablation. Joint Annual Meeting ISMRM-ESMRMB; Paris, France, 2018.
  • Sebeke L, Luo X, De Jager B, Heemels WPMH, Heijman E, Gruell H. Model Predictive control of MRI-guided HIFU for Hyperthermia. Joint Annual Meeting ISMRM-ESMRMB; Paris, France, 2018.
  • B. Kneidl, S. Limmer, G. Winter, L.H. Lindner, M. Hossann. In vitro and in vivo characterization of Irinotecan loaded DPPG2-based thermosensitive liposomes. ILS Liposome Advances and Liposome Research Days; Athens, September 2017.
  • Sebeke L, Luo X, Heijman E, de Jager B, Heemels WMPH, Grüll H. Prediction-based controller for MR-HIFU mediated Hyperthermia. 4th Symposium on Focused Ultrasound Therapy;Leipzig, Germany, 2017.
  • Sebeke L, Luo X, Heijman E, de Jager B, Heemels WMPH, Grüll H. Model-Predictive Control of MR-HIFU Hyperthermia. 4th Symposium on Focused Ultrasound Therapy;Leipzig, Germany,2017.
  • Sebeke L, Luo X, Heijman E, de Jager B, Heemels WMPH, Grüll H. A Model-based control algorithm for HIFU-based hyperthermia. 4th Symposium on Focused Ultrasound Therapy;Leipzig, Germany,2017.
  • Castillo J, Ekdawi S, Limmer S, Gruell H. Thermosensitive Liposomes as Vehicles for Local Drug Delivery via MR guided High Intensity Focused Ultrasound (MR-HIFU). MoBi 2017; Aachen Germany, 2017. (Best poster award)
  • Ferrer CJ, Bartels LW, Van der Velden TA, Mougenot C, Moonen CT, Bos C. Field drift-correction of PRFS temperature mapping using fast interleaved non selective free induction decay (FID) readouts. International Society for Magnetic Resonance in Medicine; Honolulu, HI, USA, 2017.
  • Ferrer CJ, Bos C, Kok L, Yoneyama M, Obara M, Van Stralen M, Moonen CT, Bartels LW. Magnetic Resonance Neurography (MRN) in the abdomen: feasibility of imaging the celiac plexus with motion-compensated 3D SHINKEI. International Society for Magnetic Resonance in Medicine; Honolulu, HI, USA, 2017. (Magna cum laude Merit award)
  • Kneepkens E., et al. Paramagnetic Liposomes for Hyperthermia-induced MR-guided Drug Delivery. Meeting of the European Society of Hyperthermia, Athens, Greece, 21-23 June, 2017
  • Sebeke L, Luo X, Heijman E, de Jager B, Heemels WMPH, Grüll H. Model Predictive Control for MR-HIFU induced Hyperthermia. ISTU Winter School on therapeutic ultrasound;Les Houches,France, 2017.
  • B. Kneidl, S. Limmer, L. Pointner, L.H. Lindner, G. Winter, M. Hossann. In vitro and in vivo characterization of gemcitabine loaded Phosphatidyldiglycerol-based thermosensitive liposomes. 43rd Controlled release society annual meeting and exposition; Seattle, July 2016
  • Sebeke L, Luo X, Heijman E, de Jager B, Heemels WMPH, Grüll H. Model-Based Regulation of Hyperthermia. 5th International Symposium Focused Ultrasound; Bethesda, MD, USA, 2016.
  • Ramaekers P, De Greef M, Berriet R, Moonen CT, Ries M. Numerical and experimental validation of a novel therapeutic phased array transducer aimed at sparing of the near field: the Voronoi-tesselated Fermat's Spiral. 5th International Symposium Focused Ultrasound; Bethesda, MD, USA, 2016.
  • Ferrer C, Bartels LW, Denis de Senneville B, Van Stralen M, Moonen CT, Bos C. Patient preparation influence on respiratory compensated PRFS based MR thermometry performance in the pancreas. 5th International Symposium on Focused Ultrasound; Bethesda, MD, USA, 2016.
  • Kneepkens ECM, Heijman E, Keupp J, Weiss S, Nicolay K, Grüll H. Interleaved mapping of temperature and longitudinal relaxation rate monitor drug delivery from temperature sensitive liposomes during MR-HIFU induced hyperthermia. 5th International Symposium on Focused Ultrasound; Bethesda, MD, USA, 2016.
  • Ramaekers P, Ries M, Moonen CT, De Greef M. Improving intercostal HIFU through a novel transducer design: A numerical evaluation. 5th International Symposium on Focused Ultrasound Bethesda, MD, USA, 2016.
  • Tan J, Zachiu C, Ramaekers P, Moonen CT, Ries M. Optical flow based motion tracking in the abdomen: Ultrasound vs MRI; a direct comparison. 5th International Symposium on Focused Ultrasound Bethesda, MD, USA, 2016.
  • Kneepkens ECM, Heijman E, Keupp J, Nicolay K, Gruell H. Can we simultaneously monitor temperature and drug release form temperature sensitive liposomes. NanoCity; Amsterdam, The Netherlands, 2016.
  • Engler S, Mougenot C, Keupp J, Weiss S, Heijman E, Pichardo S. On-Demand Dynamic Updating of the Temporal Resolution of Interleaved PRFS and T2 Temperature Mapping Methods for MR-HIFU. International Society for Magnetic Resonance in Medicine; Singapore, Singapore, 2016.
  • Ferrer C, Bartels LW, van Stralen M, Moonen C, Bos C. Patient Preparation by Oral Fluid Intake for Proton Resonance Frequency Shift Based MR Thermometry in the Pancreas. International Society for Magnetic Resonance in Medicine; Singapore, Singapore, 2016.
  • Ferrer C, Bos C, van Stralen M, Denis de Senneville B, Moonen C, Bartels LW. Evaluation of Common Proton Resonance Frequency Shift Based MR Thermometry Methods in the Pancreas. International Society for Magnetic Resonance in Medicine; Singapore, Singapore, 2016.
  • Van Stralen M, Petersen E, Hendrikse J, Bos C. Reproducibility of Abdominal Perfusion Imaging Using Velocity Selective Arterial Spin Labeling. International Society for Magnetic Resonance in Medicine; Singapore, Singapore, 2016.
  • S. Limmer, B. Kneidl, J. Hahn, R. Schmidt, A. Zengerle, K. Wachholz, L. Pointner, M. Hossann, L.H. Lindner. Thermosensitive liposomes encapsulating gemcitabine in an ratsoft tissue sarcoma model. 4th International Symposium on Phospholipids in Pharmaceutical research and development; Heidelberg, September 2015
  • B. Kneidl, S. Limmer, L. Pointner, M. Hossann, G. Winter, L.H. Lindner. Improvement of existing thermosensitive liposomes encapsulating gemcitabine; 30th Annual Meeting European Society of Hypterthermic oncology, Zürich, June 2015
  • B. Kneidl, S. Limmer, L. Pointner, L.H. Lindner, G. Winter, M. Hossann. Improvement of preparation method and formulation of thermosensitive liposomes encapsulating gemcitabine. 4th International Symposium on Phospholipids in Pharmaceutical research and development; Heidelberg, September 2015
  • Ries M, De Greef M, Ramaekers P, Moonen C. Sparse spherical HIFU arrays based on Fermat’s Spiral. IEEE International Ultrasonics Symposium; Taipeh, Taiwan, 2015.
  • Ramaekers P, De Greef M, Van Breugel J, Moonen C, Ries M. Preclinical evaluation of an MR-guided thermal HIFU ablation strategy using shockwaves and millisecond boiling in an in-vivo porcine liver model. IEEE International Ultrasonics Symposium; Taipeh, Taiwan, 2015.
  • Keupp J, Weiss S, Tolo J, Gruell H, Heijman E. Simultaneous T2 Mapping in Near-Field Subcutaneous Fat Layer and PRFS Temperature Mapping in the Target Region Using Fast Interleaved Sequences to Monitor MR-HIFU Sonication. International Society for Magnetic Resonance in Medicine; Toronto, Canada, 2015.
  • Van Stralen M, Sanders M, Schalkx H, Van den Bosch M, Bos C, Blankestijn P, et al. Feasibility of renal perfusion imaging using velocity selective ASL. International Society for Magnetic Resonance in Medicine; Toronto, Canada, 2015.
  • Heijman E, Weiss S, Tolo J, Keupp J. Simultaneous T2 mapping in near-field subcutaneous fat layer and PRFS temperature mapping in target region using fast interleaved sequences. . International Society for Therapeutic Ultrasound annual meeting; Utrecht, The Netherlands, 2015.
  • Ries M, De Greef M, Ramaekers P, Moonen C. A phased array transducer based on Fermat’s spiral. International Society for Therapeutic Ultrasound annual meeting; Utrecht, The Netherlands, 2015.
  • Ramaekers P, De Greef M, Van Breugel J, Moonen C, Ries M. An MRI-guided thermal ablation strategy using focused ultrasound shock waves, millisecond boiling and respiratory motion compensation in the in vivo pig liver. International Society for Therapeutic Ultrasound annual meeting; Utrecht, The Netherlands, 2015.
  • Ramaekers P, Ries M, Moonen C, De Greef M. Improved Intercostal HIFU ablation using a phased array transducer based on Fermat’s spiral. International Society for Therapeutic Ultrasound annual meeting; Utrecht, The Netherlands, 2015.
  • Heijman E, Weiss S, Tolo J, Gruell H, Keupp J. Simultaneous T2 mapping in near-field subcutaneous fat layer and PRFS temperature mapping in target region using fast interleaved sequences to monitor MR-HIFU sonication. 4th International Symposium on Focused Ultrasound; Bethesda, USA, 2014.
  • Van Stralen M, Deckers R, Bartels L, Bos C, Moonen C. Treatment analysis environment for review of MRgHIFU treatments: a multi-parametric analysis tool. 4th International Symposium on Focused Ultrasound; Bethesda, USA, 2014.
  • Holger Gruell. (Invited) MR-HIFU for image-guided local drug delivery using temperature sensitive liposomes. World Molecular Imaging Society WMIC, Philadelphia, USA, 2017
  • Holger Gruell. (Invited) Hifu systems: Technology and clinical practice. Meeting of the European Society of Hyperthermia, Athens, Greece, 21-23 June, 2017
  • Holger Gruell. (Invited) Design and applicationof temperature sensitive liposomes for hyperthermia induced drug delivery. Meeting of the European Society of Hyperthermia, Athens, Greece, 21-23 June, 2017
  • Lukas Sebeke. (Invited) Model Predictive Control for MR-HIFU induced Hyperthermia, Royal Marsden Cancer center, UK, May 9 2017.
  • Holger Gruell. (Invited) Ultrasound mediated Drug Delivery. ISTU winter school. Les houches, France, March 5 2017.
  • Juan Castillo. (Invited) Temperature sensitive liposomes for local drug delivery with HIFU. ISTU winter school. Les houches, France, March 5 2017.
  • Holger Gruell. (Invited) Hyperthermia and thermosensitive liposome treatments based on intravascular drug release, particle circulation and intratumoral accumulation. Meeting of the European Society of Hyperthermia, Zürich, Switzerland, 2015